Nanoparticle-based catalysts have been developed for catalytic nanomedicine to generate therapeutic compounds locally towards safe and effective treatment of diseases. In this talk, I will present our recent work on development of bioresponsive nanoparticles for chemodynamic, photodynamic and sonodynamic therapy by leveraging the internal or external stimuli-triggered catalytic reactions. Our nanoparticle-based catalysts have demonstrated high catalytic activity to in-situ generate reactive oxygen species efficiently to induce apoptosis and pyroptosis of tumor cells.1-4 The nanoparticles exhibited high selectivity to the tumor microenvironment. The hydroxyl radical generation-induced therapeutic effect was further enhanced cascade catalytic reactions triggered by photocatalysis.2-3 We have also shown that the nanoparticles generated oxygen bubbles and promoted the long-distance and directional movement, thus achieving target homing and deep penetration of the nanomedicine.5
References
[1] Cao, Z.; Zhang, L.; Liang, K.; Cheong, S.; Boyer, C.; Gooding, J.J.; Chen, Y.; Gu, Z. Adv. Sci. 1801155, (2018).
[2] Guo, Z.; Xie, W… Boyer, C., Zhao, L.; Gu, Z. Chem. Eng. J. 2137310, (2022).
[3] Wang X; Sun B; Dai Q; Zhu L; Gu Z; Dai L, Adv. Mater. 2408560 (2024).
[4] Zong, L; Sang, R; Zhang, X... Tao, Wei; Gu, Z. Nano Letters (2026) 26, 1, 322.
[5] Zhang, H; Cao, Z; Zhang, Q; Xu, J; Yun, SLJ; Liang, K; Gu, Z. Small 16, e2002732, (2020).