The Vortex Fluidic Device (VFD) is a microfluidic continuous flow reactor consisting of a high-speed rotating tube (2000 – 9000 rpm).1 As the rotation speed increases, centrifugal forces push the reaction mixture up the tube forming thin films on the walls which create high shear forces resulting in accelerated reaction rates.1 Previous applications of the VFD include pharmaceutical synthesis,2 biodiesel production3 and famously ‘unboiling an egg’ via protein folding which won an Ig Nobel Prize.1
At Heriot-Watt University, we have successfully reduced reaction times of visible light catalysed photooxidations via singlet oxygen from multiple hours to just a few minutes by taking advantage of the VFD’s high mass transfer abilities.4 Current focus has been on automating the VFD to provide prospect of a rapid experimentation device. Control over the rotation speed, tilt angle and various portable liquid handlers provides the opportunity to run consecutive test experiments to continuously optimise processes.
Growing the system further observes the integration of machine learning tools, such as Bayesian Optimisation and Design of Experiments. Investigating these tools with the VFD provides an effective method to optimise experimental parameters to achieve the best conditions to give the highest yield in the shortest time. Ultimately showcasing the VFD as an efficient automated experimentation platform.