The South West Australia Ecoregion, extending from Shark Bay to Esperance, is a Global Biodiversity Hotspot with exceptionally diverse yet underexplored marine biodiversity. As part of the Biota Pipeline, a translational discovery program linking Western Australian biodiversity to biomedical and commercial outcomes, this work focuses on marine sponges from Busselton Jetty, Australia’s largest artificial reef and a globally recognised marine tourism icon. The Jetty supports a diverse marine ecosystem with a sponge community featuring chemically rich secondary metabolite profiles that reflect complex ecological interactions within Geographe Bay. Here, we present the discovery workflow and results to date, exploring these chemically diverse sponge-derived metabolites for selective activity against liver cancer as part of the broader translational objectives of the Biota Pipeline. Delivered in collaboration with Busselton Jetty Inc., this work demonstrates a community-embedded model for marine biodiscovery that aligns conservation, public engagement, and biomedical research, while advancing Western Australian marine biodiversity toward translational health and innovation outcomes.