Hydroxyanthraquinones are naturally derived cyclic compounds with a variety of biological functions. Their delocalised nature gives rise to a number of spectacular colours through resonance stabilisation at the different functional groups around the ring. The downside to their high resonance capability is the stability of potential metal chelates.1 Facile hydrolysis of the O,O di-ketonate binding mode has been observed by the Andrews group to occur with organometallic based complexes of group 13, rendering them unable to undergo biological assessment. Therefore, we turned our attention to larger group 15 organometallics, tris/tetra-phenyl Sb(V), as the metal template for stabilisation. The resultant complexes were observed to be stable to hydrolysis under ambient conditions giving rise to six distinctive Sb(V) complexes. These highly coloured complexes were analysed via single-x-ray crystallography to ascertain the binding mode of the anthraquinone. Interestingly, the triphenyl complexes exhibited bidentate binding mode of the anthraquinone through a double deprotonation of both hydroxyls, with the sixth position occupied by a solvent molecule. For the tetra-aryls, a monodentate binding of the most acidic 2nd position was noted. With a high degree of aqueous stability, the complexes underwent biological assessment toward Leishmania parasites, the causative agent of the neglected disease which unfortunately incorporates detrimental antimonials as the frontline treatment.2 The activity of these Sb(V) complexes was obtained, highlighting a good degree of selective activity. Preliminary fluorescence on the complexes has alluded to potential use in identifying the localisation intracellularly through microscopy. These studies are currently underway.