Poster Presentation Royal Australian Chemical Institute National Congress 2026

Utilising fluorocarbons in palladium catalysed oxidative transfer fluorination (#109)

Chi Bong Eric Chao 1 , Indraraj Malav 1 , Max Coles 1 , Rowan Young 1
  1. School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia

Fluorinated scaffolds are highly featured in medicine and agrochemicals due to the modification of chemical properties it possesses when incorporated into organic molecules.1,2 One of the main pathways for the preparation of organofluorine compounds is via electrophilic fluorination by using nitrogen-based fluorinating reagents, which have been dominating this field of work due to their better selectivities, stabilities and reactivities when compared with other oxidative fluorinating reagents and methods.3 The Young group is currently focusing on the development of an unprecedented carbon-based electrophilic fluorinating reagent to offer an alternative and complimentary pathway to current methodologies.

The advantages of utilising fluorocarbons as base materials for electrophilic reagents centres around their mass production without the need of generating fluorine gas. Indeed, negative cost waste fluorocarbons offer the opportunity for formally recycling fluorine, without the need to ever generate molecular fluorine.

Transfer fluoridation, where a fluoride is transferred from one organic substrate to another, has recently been reported.4,5 However, the formal transfer of fluorine (i.e. transfer fluorination), which is a formal redox process, is yet to be reported. This poster discusses the development and application of such a technology via palladium catalysis.

 

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