Acid mine drainage (AMD) is a serious environmental hazard that is expensive to remediate, with impacted mine sites spread across the globe. As such, upcycling of this waste to value-added products can incentivise proper handling and environmental responsibility, especially when the upcycled products can be utilised in-house. In this work, we explore the upcycling of AMD sludge and wastewater to produce metal-organic frameworks (MOFs), a class of advanced sorbent materials that are attracting growing industry attention for their performance in diverse applications of interest to the resources industry, such as carbon capture, critical mineral recovery, and wastewater treatment. We show that common and industrially relevant MOFs, such as MIL-100, can be successfully produced from simulated and real AMD waste streams with only moderate loss of porosity compared to MOFs produced from lab-grade reagents. We will examine the impact of different iron sources, co-contaminants, and acid contents on the properties of the resulting MOF, and discuss the opportunities and barriers involved in successful implementation of this process.