Investigation into the Phytotoxic Structure-Activity Relationships of the Antibacterial Tedizolid
Established drug molecules are a rich source of herbicidal compounds with novel modes of action. Linezolid, an oxazolidinone antibiotic which binds to the ribosome and inhibits microbial translation, is herbicidal through the inhibition of chloroplast translation. Here, the second-generation oxazolidinone antibiotic tedizolid was investigated for its phytotoxic structure-activity relationships. Seeking to divorce its antibacterial activity from its herbicidal activity, chemical modification and extension of the azole ring were introduced utilising click chemistry with a variety of synthesised azides. Preliminary evaluation of these analogues has revealed numerous herbicidally-active compounds.