Medical devices continue to improve the health and quality of life for people all over the world. However, the use of these devices can also be associated with serious clinical complications and even death due to device-related infections. Over the past few decades, a broad range of biomaterial coating strategies have been investigated to prevent these device-related infections. In particular, the chemical modification of device surfaces with thin polymeric coatings has been demonstrated to be a promising strategy. This work developed multifunctional antibacterial coatings for biomedical devices whereby the coating would exhibit low bacterial adherence and could release antibacterial agents such as antibiotics and quorum sensing inhibitors. Antifouling polymer coatings were achieved by synthesising copolymers made from the hydrophilic monomers carboxybetaine acrylamide (CBAA), N-(2-hydroxypropyl) acrylamide (HPAm) and N, N-dimethylacrylamide (DMA) as well as the photoreactive monomer N-benzophenone acrylamide (BPA). Additional antibacterial properties were achieved by conjugating antibiotics such as ciprofloxacin and moxifloxacin via the synthesis of terpolymers. Here, the antibiotics were bound to the polymers via hydrolysable linkers which can release the active form of the antibiotic. The relationship between drug release kinetics on the one hand and polymer architecture and different linker chemistries on the other was investigated. All polymers were synthesised via reversible addition-fragmentation chain transfer (RAFT) polymerisation to achieve control over the polymer molecular weight and architecture. Stable polymer coatings on substrates were achieved in a one-step method by UV irradiation. This method achieved the covalent crosslinking of deposited polymers while also covalently immobilising these polymers onto the substrate via pendant benzophenone moieties. The antibacterial properties and the bactericidal activity of antibiotic containing coatings against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) were evaluated. The results demonstrate that single layer ciprofloxacin or moxifloxacin containing coatings could significantly reduce bacterial attachment compared to pristine polyethylene terephthalate (PET) control substrates only when the minimum therapeutic concentrations of the antibiotics could be achieved. The double layer moxifloxacin containing coating, with a hydrophilic HPAm based coating layer on the top and a moxifloxacin containing layer underneath, significantly reduced bacterial attachment against both E. coli and S. aureus compared to pristine PET control substrates and the proliferation of planktonic bacteria both on the surface and in the vicinity of samples was inhibited.