Dendronised polymers are a unique class of cationic polymer which have outcompeted a commercial liposomal reagent in gene delivery(1). Cationic polymers represent a distinct modality of gene therapy, distinct from the massively-popular lipid nanoparticles (LNPs) which have swept the field in light of the Covid-19 pandemic. However, cationic polymers have many properties which confer them with unique advantages in comparison with LNPs; most notably of which is their functionalisation capacity. Dendronised polymers dial this to the max; building on the work of Tomalia's famous dendrimers(2), dendronised polymers are typically thought of as linear polymers with hyperbranched dendrimer-like side-chains(1,3). Our poly(amidoamine) (PAMAM)-based dendronised polymers present a nigh-innumerable amount of cationic amine surface groups which allow for nucleic acid condensation, cellular uptake, and make for potential sites of functionalisation. In this work, we have synthesised an as-yet unseen subclass comprising ‘radial’ dendronised polymers. We have investigated a library of this subclass for in vitro gene delivery of multiple genetic cargoes and present the results of that work herein.