Antimicrobial drug resistance is an ever-increasnig problem in modern medical care. Sublethal chemotherapy of bacterial infections can select for resistant organisms allowing drug resistant strains to flourish. Our approach to overcome this is to target bacterial motility in order to prevent infection without killing the bacteria. As a model infectious organism, Campylobacter jejuni was chosen as its chemosensors have been well studied and are known to respond to certain carbohydrates.1 We have modified naturally abundant polysaccharides such as chitosan with differing oligosaccharide motifs (often used in drug delivery2) in order to interfere with chemosensors responsible for bacterial motility. Our results have shown this to be quite a promising technique toward limiting bacterial movement and this work will be presented. In addition, we have purified significant quantities of the chemosensor Tlp10 for further study with these polysaccharides.