Biomaterials play a crucial role in modern biomedical engineering and are widely applied in implantology, tissue engineering, and controlled drug delivery systems. The growing interest in this field results from the increasing demand for biocompatible and biodegradable materials capable of supporting tissue regeneration.
This study focuses on a biodegradable polymeric biomaterial - poly(glycerol sebacate) (PGS). The experiment investigates material degradation as a function of time under various environmental conditions. PGS was synthesized and crosslinked to obtain poly(glycerol sebacate) urethane (PGSU). Quantitative and qualitative analyses were performed to characterize the degradation process, including evaluation of mass changes, chemical structure, and surface morphology.
The results reveal significant changes in biomaterial properties depending on the degradation environment and exposure time. These findings demonstrate the strong influence of environmental conditions on the degradation behavior of PGSU and highlight its potential applicability in tissue engineering and biomedical systems requiring controlled biodegradation.
This research was funded by the Polish Ministry of Science and Higher Education – Wsparcie studentów w zakresie podniesienia ich kompetencji i umiejętności [W187].